Alprostadil Injection 500 mcg (Prostacel)

Product Overview

Alprostadil Injection 500 mcg, marketed under the brand name Prostacel and manufactured by Celon Laboratories Ltd, is a prescription medication indicated for the treatment of erectile dysfunction (ED) in adult men. The product is supplied as a sterile, lyophilized powder in a 1 ml vial, intended for reconstitution and subsequent intracavernosal administration. Each pack is available in several size options, including 1, 3, or 6 injections per package, allowing patients and clinicians to select the most appropriate treatment regimen. This medication belongs to the class of prostaglandin E1 analogues and functions by enhancing the smooth‑muscle relaxation that initiates an erection. For more information on erectile dysfunction, refer to the National Institutes of Health (NIH) resource on the condition NIH – Erectile Dysfunction.

What is Alprostadil Injection (Prostacel)

Alprostadil is a synthetic analogue of prostaglandin E1, a naturally occurring lipid that induces vasodilation of the penile corpora cavernosa. When administered directly into the penile tissue, it promotes the relaxation of smooth muscle and increases blood flow, facilitating an erection sufficient for sexual activity. The 500 mcg dosage represents a standardized strength that balances efficacy with a manageable side‑effect profile. As an FDA‑approved drug, Alprostadil Injection is listed in the Drugs.com database with detailed prescribing information Drugs.com – Alprostadil. The medication is supplied by Celon Laboratories Ltd, a manufacturer that complies with Good Manufacturing Practices (GMP) and provides a patient‑information leaflet with each shipment.

Uses and Benefits

The primary use of Alprostadil Injection is to treat moderate to severe erectile dysfunction when oral phosphodiesterase‑5 inhibitors are ineffective or contraindicated. Clinical studies have demonstrated that intracavernosal Alprostadil can produce erections in up to 70 % of treated men, with onset of action typically within 5–10 minutes. Benefits include a rapid onset, a short duration of effect, and the ability to titrate dose according to individual response. Because it is delivered locally, systemic exposure is minimal, which reduces the likelihood of certain cardiovascular side effects associated with oral ED drugs. Additional advantages include compatibility with a wide range of patient profiles, including those with mild cardiovascular disease, provided they are cleared by a healthcare professional.

How It Works

Alprostadil mimics the actions of endogenous prostaglandin E1, binding to EP receptors on the smooth muscle of the penile erectile tissue. This binding triggers a cascade that increases intracellular cyclic adenosine monophosphate (cAMP), leading to relaxation of the trabecular smooth muscle and dilation of penile arteries. The resulting increase in blood inflow produces an erection that can be sustained for several minutes to an hour, depending on individual physiology and stimulation. The mechanism of action is distinct from oral phosphodiesterase‑5 inhibitors, making Alprostadil a valuable option for patients who do not respond to those agents. For a deeper scientific review, see the PubMed database entry on Alprostadil and erectile dysfunction PubMed – Alprostadil.

Dosage Guidelines

Dosage of Alprostadil Injection must be individualized by a qualified healthcare provider. The usual starting dose ranges from 10 µg to 40 µg per injection, administered into the lateral aspect of the penis. The dose may be adjusted based on efficacy and tolerability, but should never exceed the maximum recommended amount without medical supervision. Patients are advised to use a new, sterile needle for each injection and to rotate injection sites to minimize tissue irritation. It is essential to follow the dosing schedule provided on the product label and to avoid self‑administration without prior instruction from a clinician. For detailed dosing recommendations, consult the official FDA drug label FDA – Alprostadil Label.

Side Effects

Like all medications, Alprostadil Injection can cause adverse effects. The most commonly reported side effects include mild to moderate penile pain, bruising, swelling, and transient dizziness. In rare cases, patients may experience priapism—a prolonged erection lasting more than four hours—which requires immediate medical attention to prevent tissue damage. Systemic side effects such as hypotension or flushing are uncommon but possible, especially if the drug is inadvertently administered intravenously. Patients should contact their physician if they notice persistent pain, signs of infection at the injection site, or any unexpected symptoms. For comprehensive safety information, refer to the MedlinePlus resource on erectile dysfunction treatments MedlinePlus – Erectile Dysfunction.

Warnings and Precautions

Alprostadil Injection is contraindicated in individuals with a known hypersensitivity to the drug or any of its excipients. It should not be used in patients with a recent history of myocardial infarction, severe cardiovascular instability, or uncontrolled arrhythmias without specialist evaluation. Caution is advised when co‑administering with other vasoactive agents, as additive hypotensive effects may occur. Men who have undergone recent penile surgery or who have structural abnormalities that could impede injection should discuss these conditions with their physician before use. The medication is intended for adult men only and is not indicated for use in women or children. Always store the vials at the temperature range specified on the packaging and keep them out of reach of unauthorized persons.

Frequently Asked Questions

Q1: How often can I use Alprostadil Injection?
A: The dosing frequency is determined by a healthcare professional, but typical regimens involve using the medication no more than once or twice per week, with at least 24 hours between injections to allow tissue recovery.

Q2: Can Alprostadil be combined with oral erectile dysfunction pills?
A: Combining Alprostadil with oral phosphodiesterase‑5 inhibitors is generally not recommended without medical supervision, as the combined effect may increase the risk of priapism or severe hypotension.

Q3: What should I do if I experience a prolonged erection?
A: If an erection lasts longer than four hours, seek emergency medical care immediately, as prolonged priapism can cause permanent tissue damage.

Q4: Is the medication safe for men with diabetes?
A: Clinical data suggest that Alprostadil can be used in men with diabetes when monitored by a clinician, but patients should discuss their overall cardiovascular health and any other comorbidities with their provider.

Q5: Where can I find the patient information leaflet?
A: The leaflet is included in each shipment and is also available for download on the manufacturer’s website or through the FDA label link provided above.

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